Nonselective Alpha Blockers

• These work on  alpha receptors
• vasodilates aka ↓ BP (alpha 1)
• & blocks NE feedback control (alpha 2)

• primarily used to prevent cell death/tissue sloughing r/t IV DA or NE extravasation/infiltration (causes local vasodilation & return of blood flow to the area)
• can be used for pheochromocytoma Dx or mgmt of severe HTN reactions s/p pheochromocytoma surgery

CAD or MI

Cautions

• pregnancy & lactation

Adverse Effects

• (orthostatic) hypotension, arrhythmia (tachy), flushing
• angina, MI, CVA

Kinetics

• Rapidly absorbed after IV or IM injection
• Metabolized in the liver and excreted in the urine 

Drug

• Phentolamine (Regitine)

Drug Interactions

• ↓ effectiveness ephedrine & epinephrine 
• ↑ hypotension if combined w/ alcohol

Nursing Mgmt

• monitor CNS & CV status

joshmrivera 11:56 AM adrenergic blockers , alpha antagonists , ANS , pharmacology , phentolamine , SNS No comments

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